Welcome to the Cell Polarity & Morphogenesis lab

April 15, 2016

 

The control of epithelial cell shape and cell stacking is crucial for the proper development of tissues and organs accross phyla. Epithelial cell shape changes are based on the regulated formation or suppression of cell-cell contacts. Ultimately, cell-cell contact rearrangements have a global effect on organ shape. However, much of the cellular, genetic and molecular basis that orchestrate cell-cell contact remodelling during development remain to be discovered. To this end, we are making use of the developing fly retinal neuroepithelium. Retina morphogenesis relies on a coordinated sequence of interdependent morphogenetic events and polarized cell behaviors that include apical cell constriction, localized alignment of groups of cells, and cell-cell contact remodelling.

Related publications   |  Pichaud, Dev. Biol., 2013 [PDF]  | Robertson et al., Development,, 2012 [PDF] | Corrigall et al., Dev. Cell, 2007 [PDF]